The true story of the life of cellist Jacqueline du Pré (Emily Watson), focusing upon her turbulent relationship with her family. Sister Hilary (Rachel Griffiths) exhibits almost as much musical talent as a child, but decides to eschew fame for a more conventional life, marrying conductor Kiffer Kinzi (David Morrissey). Jackie, meanwhile, quickly rises through the ranks on the international concert circuit and becomes engaged to renowned pianist Daniel Barenboim (James Frain). However, at the pinnacle of Jackie's success, tragedy strikes - her fingers begin to numb, her ability to play diminishes, and her mental state becomes ever more precarious.